Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease
Identifieur interne : 000C12 ( Main/Corpus ); précédent : 000C11; suivant : 000C13Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease
Auteurs : Nobutaka Hattori ; Hiroyo Yoshino ; Masashi Tanaka ; Hiroshi Suzuki ; Yoshikuni MizunoSource :
- Genomics [ 0888-7543 ] ; 1997.
English descriptors
Abstract
We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ2= 7.53,df= 2,P= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,P= 0.0099 < 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.
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DOI: 10.1006/geno.1997.5192
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Yoshino</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</mods:affiliation></affiliation></author><author><name sortKey="Tanaka, Masashi" sort="Tanaka, Masashi" uniqKey="Tanaka M" first="Masashi" last="Tanaka">Masashi Tanaka</name><affiliation><mods:affiliation>Department of Gene Therapy, Gihu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gihu, 505-0116, Japan</mods:affiliation></affiliation></author><author><name sortKey="Suzuki, Hiroshi" sort="Suzuki, Hiroshi" uniqKey="Suzuki H" first="Hiroshi" last="Suzuki">Hiroshi Suzuki</name><affiliation><mods:affiliation>Department of Bioscience, Faculty of Molecular Biology and Biotechnology, Fukui Prefectural Unniversity, Matsuoka-cho, Yoshida-gun, Fukui, 910-1195, Japan</mods:affiliation></affiliation></author><author><name sortKey="Mizuno, Yoshikuni" sort="Mizuno, Yoshikuni" uniqKey="Mizuno Y" first="Yoshikuni" last="Mizuno">Yoshikuni Mizuno</name><affiliation><mods:affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Genomics</title><title level="j" type="abbrev">YGENO</title><idno type="ISSN">0888-7543</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">49</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="52">52</biblScope><biblScope unit="page" to="58">58</biblScope></imprint><idno type="ISSN">0888-7543</idno></series><idno type="istex">A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE</idno><idno type="DOI">10.1006/geno.1997.5192</idno><idno type="PII">S0888-7543(97)95192-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0888-7543</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>24-kDa subunit</term><term>Parkinson disease</term><term>complex I</term><term>genetic predisposition</term><term>mitochondria</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ2= 7.53,df= 2,P= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,P= 0.0099 < 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Nobutaka Hattori</name><affiliations><json:string>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</json:string></affiliations></json:item><json:item><name>Hiroyo Yoshino</name><affiliations><json:string>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</json:string></affiliations></json:item><json:item><name>Masashi Tanaka</name><affiliations><json:string>Department of Gene Therapy, Gihu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gihu, 505-0116, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Suzuki</name><affiliations><json:string>Department of Bioscience, Faculty of Molecular Biology and Biotechnology, Fukui Prefectural Unniversity, Matsuoka-cho, Yoshida-gun, Fukui, 910-1195, Japan</json:string></affiliations></json:item><json:item><name>Yoshikuni Mizuno</name><affiliations><json:string>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetic predisposition</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>complex I</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>24-kDa subunit</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mitochondria</value></json:item></subject><language><json:string>eng</json:string></language><abstract>We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ2= 7.53,df= 2,P= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,P= 0.0099 > 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.</abstract><qualityIndicators><score>6.674</score><pdfVersion>1.2</pdfVersion><pdfPageSize>540 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1122</abstractCharCount><pdfWordCount>4586</pdfWordCount><pdfCharCount>28448</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>174</abstractWordCount></qualityIndicators><title>Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</title><pii><json:string>S0888-7543(97)95192-2</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>49</volume><pii><json:string>S0888-7543(00)X0070-5</json:string></pii><pages><last>58</last><first>52</first></pages><issn><json:string>0888-7543</json:string></issn><issue>1</issue><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><title>Genomics</title><publicationDate>1998</publicationDate></host><categories><wos><json:string>BIOTECHNOLOGY & APPLIED MICROBIOLOGY</json:string><json:string>GENETICS & HEREDITY</json:string></wos></categories><publicationDate>1997</publicationDate><copyrightDate>1998</copyrightDate><doi><json:string>10.1006/geno.1997.5192</json:string></doi><id>A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1998</date></publicationStmt><notesStmt><note>Nucleotide sequence data from this article have been deposited with the DDBJ, EMBL, and GenBank Data Libraries under Accession Nos. D88542–D88548.</note><note>T. NagatsuH. NarabayashiM. Yoshida</note><note type="content">Section title: Regular Article</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</title><author><persName><forename type="first">Nobutaka</forename><surname>Hattori</surname></persName><affiliation>To whom correspondence should be addressed. Telephone: ++81-3-5802-1072. Fax: ++81-3-3813-7440. E-mail:nhattori@med.juntendo.ac.jp.</affiliation><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation></author><author><persName><forename type="first">Hiroyo</forename><surname>Yoshino</surname></persName><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation></author><author><persName><forename type="first">Masashi</forename><surname>Tanaka</surname></persName><affiliation>Department of Gene Therapy, Gihu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gihu, 505-0116, Japan</affiliation></author><author><persName><forename type="first">Hiroshi</forename><surname>Suzuki</surname></persName><affiliation>Department of Bioscience, Faculty of Molecular Biology and Biotechnology, Fukui Prefectural Unniversity, Matsuoka-cho, Yoshida-gun, Fukui, 910-1195, Japan</affiliation></author><author><persName><forename type="first">Yoshikuni</forename><surname>Mizuno</surname></persName><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation></author></analytic><monogr><title level="j">Genomics</title><title level="j" type="abbrev">YGENO</title><idno type="pISSN">0888-7543</idno><idno type="PII">S0888-7543(00)X0070-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">49</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="52">52</biblScope><biblScope unit="page" to="58">58</biblScope></imprint></monogr><idno type="istex">A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE</idno><idno type="DOI">10.1006/geno.1997.5192</idno><idno type="PII">S0888-7543(97)95192-2</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1998</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ2= 7.53,df= 2,P= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,P= 0.0099 < 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson disease</term></item><item><term>genetic predisposition</term></item><item><term>complex I</term></item><item><term>24-kDa subunit</term></item><item><term>mitochondria</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1997-12-18">Registration</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YGENO</jid><aid>95192</aid><ce:pii>S0888-7543(97)95192-2</ce:pii><ce:doi>10.1006/geno.1997.5192</ce:doi><ce:copyright type="full-transfer" year="1998">Academic Press</ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>Nucleotide sequence data from this article have been deposited with the DDBJ, EMBL, and GenBank Data Libraries under Accession Nos. D88542–D88548.</ce:note-para></ce:article-footnote><ce:article-footnote><ce:label>☆☆</ce:label><ce:note-para>T. NagatsuH. NarabayashiM. Yoshida</ce:note-para></ce:article-footnote><ce:dochead><ce:textfn>Regular Article</ce:textfn></ce:dochead><ce:title>Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</ce:title><ce:author-group><ce:author><ce:given-name>Nobutaka</ce:given-name><ce:surname>Hattori</ce:surname><ce:cross-ref refid="GE975192A0"><ce:sup>a</ce:sup></ce:cross-ref><ce:cross-ref refid="GE975192FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Hiroyo</ce:given-name><ce:surname>Yoshino</ce:surname><ce:cross-ref refid="GE975192A0"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Masashi</ce:given-name><ce:surname>Tanaka</ce:surname><ce:cross-ref refid="GE975192A1"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Hiroshi</ce:given-name><ce:surname>Suzuki</ce:surname><ce:cross-ref refid="GE975192A2"><ce:sup>c</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Yoshikuni</ce:given-name><ce:surname>Mizuno</ce:surname><ce:cross-ref refid="GE975192A0"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="GE975192A0"><ce:label>a</ce:label><ce:textfn>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</ce:textfn></ce:affiliation><ce:affiliation id="GE975192A1"><ce:label>b</ce:label><ce:textfn>Department of Gene Therapy, Gihu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gihu, 505-0116, Japan</ce:textfn></ce:affiliation><ce:affiliation id="GE975192A2"><ce:label>c</ce:label><ce:textfn>Department of Bioscience, Faculty of Molecular Biology and Biotechnology, Fukui Prefectural Unniversity, Matsuoka-cho, Yoshida-gun, Fukui, 910-1195, Japan</ce:textfn></ce:affiliation><ce:footnote id="GE975192FN1"><ce:label>1</ce:label><ce:note-para>To whom correspondence should be addressed. Telephone: ++81-3-5802-1072. Fax: ++81-3-3813-7440. E-mail:nhattori@med.juntendo.ac.jp.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="18" month="9" year="1997"></ce:date-received><ce:date-accepted day="18" month="12" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ<ce:sup>2</ce:sup>= 7.53,<ce:italic>df</ce:italic>= 2,<ce:italic>P</ce:italic>= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,<ce:italic>P</ce:italic>= 0.0099 < 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Parkinson disease</ce:text></ce:keyword><ce:keyword><ce:text>genetic predisposition</ce:text></ce:keyword><ce:keyword><ce:text>complex I</ce:text></ce:keyword><ce:keyword><ce:text>24-kDa subunit</ce:text></ce:keyword><ce:keyword><ce:text>mitochondria</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Genotype in the 24-kDa Subunit Gene (NDUFV2) of Mitochondrial Complex I and Susceptibility to Parkinson Disease</title></titleInfo><name type="personal"><namePart type="given">Nobutaka</namePart><namePart type="family">Hattori</namePart><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation><description>To whom correspondence should be addressed. Telephone: ++81-3-5802-1072. Fax: ++81-3-3813-7440. E-mail:nhattori@med.juntendo.ac.jp.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroyo</namePart><namePart type="family">Yoshino</namePart><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Masashi</namePart><namePart type="family">Tanaka</namePart><affiliation>Department of Gene Therapy, Gihu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gihu, 505-0116, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroshi</namePart><namePart type="family">Suzuki</namePart><affiliation>Department of Bioscience, Faculty of Molecular Biology and Biotechnology, Fukui Prefectural Unniversity, Matsuoka-cho, Yoshida-gun, Fukui, 910-1195, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshikuni</namePart><namePart type="family">Mizuno</namePart><affiliation>Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8431, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateValid encoding="w3cdtf">1997-12-18</dateValid><copyrightDate encoding="w3cdtf">1998</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We analyzed the gene encoding the 24-kDa subunit of mitochondrial complex I, which has been implicated in the pathogenesis of Parkinson disease (PD). We set out to identify a polymorphism in the 24-kDa subunit gene (NDUFV2) in patients with PD and determine whether genetic polymorphism of this gene is associated with a higher risk of PD. The subjects comprised 126 patients with PD, and the control group comprised 113 unrelated individuals without neurodegenerative disorders. A novel polymorphism (Ala29Val) in the mitochondrial targeting sequence of NDUFV2 was found in patients with PD. The distribution of the three genotypes was significantly different between the two groups (χ2= 7.53,df= 2,P= 0.023). The frequency of homozygotes for the mutation was significantly higher in PD patients (23.8%) than in control subjects (11.5%, Fisher's exact test,P= 0.0099 < 0.01). The risk of developing PD associated with homozygosity for this mutation was calculated as 2.40 (95% CI: 1.18–4.88). NDUFV2 constitutes one genetic risk factor for PD, and the mutation may well be a cause of complex I deficiency in this disease.</abstract><note>Nucleotide sequence data from this article have been deposited with the DDBJ, EMBL, and GenBank Data Libraries under Accession Nos. D88542–D88548.</note><note>T. NagatsuH. NarabayashiM. Yoshida</note><note type="content">Section title: Regular Article</note><subject lang="en"><genre>Keywords</genre><topic>Parkinson disease</topic><topic>genetic predisposition</topic><topic>complex I</topic><topic>24-kDa subunit</topic><topic>mitochondria</topic></subject><relatedItem type="host"><titleInfo><title>Genomics</title></titleInfo><titleInfo type="abbreviated"><title>YGENO</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19980401</dateIssued></originInfo><identifier type="ISSN">0888-7543</identifier><identifier type="PII">S0888-7543(00)X0070-5</identifier><part><date>19980401</date><detail type="volume"><number>49</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>166</end></extent><extent unit="pages"><start>52</start><end>58</end></extent></part></relatedItem><identifier type="istex">A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE</identifier><identifier type="DOI">10.1006/geno.1997.5192</identifier><identifier type="PII">S0888-7543(97)95192-2</identifier><accessCondition type="use and reproduction" contentType="">© 1998Academic Press</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Academic Press, ©1998</recordOrigin></recordInfo></mods></metadata><enrichments><istex:catWosTEI uri="https://api.istex.fr/document/A5FD5AA5879D4DE51943E2FF405F2AE411B3BFDE/enrichments/catWos"><teiHeader><profileDesc><textClass><classCode scheme="WOS">BIOTECHNOLOGY & APPLIED MICROBIOLOGY</classCode><classCode scheme="WOS">GENETICS & HEREDITY</classCode></textClass></profileDesc></teiHeader></istex:catWosTEI></enrichments><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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